The first objective of the thesis will be dedicated to the design and the characterization of the hydrogels composed of biomacromolecules and nanoparticles containing therapeutics. A first strategy will employ the NIR light irradiation to trigger the release of the therapeutics from the hydrogel (photothermic therapy). A second approach will be oriented towards the utilization of polymers responding to an electrical stimulus.
The work program will include the modification of hydrophilic biopolymers, the formulation of the hydrogel and physicochemical characterizations such as NMR, UV-vis, IR, SEC, electrochemistry, zeta potentiometry, rheology and electronic microscopy. The release properties of the active material will be characterized by suitable methods to test their response to light/electric stimulation. The cytocompatibility of these hydrogels will be evaluated in collaboration with INSERM U1008 (Advanced Drug Delivery Systems) which will support biological and microbiological characterization as well as the in vitro evaluations. Interactions with partners in other specialties will be required to combine the stimuli responsive hydrogels with electronic (sensor) and textile components of the connected wound dressing.
